2022 Vol. 43, No. 9

Original Articles Basic of Medicine
Effects of miR-125a-3p on Atherosclerotic Plaque, M1/M2 Macrophages, MMP-9 and VEGF
Yanlong LIU, Xuefeng GUANG, Xiaolong YIN, Hailong DAI
2022, 43(9): 1-6. doi: 10.12259/j.issn.2095-610X.S20220915
Abstract(3347) HTML PDF(135) Cited By (8)
Abstract:
Objective To investigate the effects of miR-125a-3p inhibitors on the atherosclerotic plaque formation, M1/M2 macrophages, MMP-9 and VEGF. Methods Fifteen healthy adult male Japanese big-eared rabbits were randomly divided into 3 groups with 5 rabbit...
Effects of Dose-response and Time-dependent of Endotoxin on Proliferation of Human Umbilical Cord Mesenchymal Stem Cells
Wei YUAN, Mingyao MENG, Xinxin LI, Jingjing XIONG, Meng LI, Jia CAO, Mei LIU, Zongliu HOU, Yongkun HUANG
2022, 43(9): 7-12. doi: 10.12259/j.issn.2095-610X.S20220928
Abstract(3571) HTML PDF(37)
Abstract:
Objective To investigate the effects of dose-response and time-dependent of endotoxin on the proliferation of human umbilical cord mesenchymal stem cells(hUC-MSCs). Methods The hUC-MSCs were cultured in stem cell culture medium containing different c...
Clinical Research
The Expression of PD-L1, BRAFV600E, CD68 Protein and the Significance of Tumor Infiltrating Lymphocytes in the Diagnosis of Malignant Melanoma
Xilan WU, Hong SHEN, Susheng SHI, Zhihui ZHANG, Lei GUO, Fang WANG
2022, 43(9): 13-18. doi: 10.12259/j.issn.2095-610X.S20220923
Abstract(3165) HTML PDF(29) Cited By (5)
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Objective To analyze the significance of PD-L1, BRAFV600E, CD68 protein expressions and tumor infiltrating lymphocytes (TIL) in the diagnosis of malignant melanoma. Methods High-throughput tissue microarray technology and immunohistochemical methods...
Comparative Analysis of Behavioral and Psychological Symptoms of Dementia in Patients with Alzheimer's Disease and Mild Cognitive Impairment
Huiping HE, Yaowei HE, Zonglin SHEN, Xiaoxiao SONG, Baoluo LI, Hongyan JIANG
2022, 43(9): 19-23. doi: 10.12259/j.issn.2095-610X.S20220913
Abstract(3692) HTML PDF(26) Cited By (4)
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Objective To provide the guidance for the management of patients with Alzheimer’s disease (AD) and mild cognitive impairment (MCI) by analyzing the similarities and differences between them. Methods The Neuropsychiatric Inventory (NPI) was used to a...
The Value of HCT-ALB in the Early Diagnosis of Sepsis-associated Encephalopathy
Congxin LI, Dapeng ZHANG, Lingjie MU, Jilin YANG, Lihong DONG, Yijie WANG
2022, 43(9): 24-28. doi: 10.12259/j.issn.2095-610X.S20220901
Abstract(3410) HTML PDF(21) Cited By (1)
Abstract:
Objective To find simple and reliable clinical quantitative indicators for the early diagnosis of SAE. Methods Seventy-two septic patients who were admitted to ICU from April 2020 to April 2022, including 31 with sepsis encephalopathy (SAE) and 41 w...
The Role of Maternal Serum MMPs and SAA in the Pathogenesis of Preterm Premature Rupture of Membranes
Sainan LI, Wenjin QI, Raoyang KE, Rong HUANG, Guangqiong YANG
2022, 43(9): 29-33. doi: 10.12259/j.issn.2095-610X.S20220905
Abstract(2946) HTML PDF(16) Cited By (2)
Abstract:
Objective To investigate the relationships of matrix metalloproteinase-1 (MMP-1), matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-9 (MMP-9) and serum amyloid A (SAA) with the premature rupture of membranes. Methods Thirty cases of prema...
Study on the Correlation between Late-onset Breast Milk Jaundice and Defecation Frequency in Infants
Jingjing XIONG, Yuanyuan ZHANG, Meng LI, Yan CHEN, Mei LIU, Yongkun HUANG
2022, 43(9): 34-37. doi: 10.12259/j.issn.2095-610X.S20220925
Abstract(3272) HTML PDF(23) Cited By (1)
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Objective To analyze the correlation factors of late-onset breast-feeding jaundice (LBMJ), and provide the reference for the study of LBMJ etiology. Methods 102 full-term breast-fed infants aged 0-6 months from the First Affiliated Hospital of Kunmi...
Prediction of Delivery Mode by Transperineal Ultrasound during the Active Phase of the First Stage Labor
Yuxin WEI, Shuwen LIANG, Chun CHEN, Xiuling LI, Shu ZHU, Fang YAN
2022, 43(9): 38-42. doi: 10.12259/j.issn.2095-610X.S20220908
Abstract(3354) HTML PDF(18) Cited By (7)
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Objective To investigate the value of angle of progression progression (AOP), fetal head descent distance (PD) and fetal head to pubic symphysis (HSD) in predicting the mode of delivery during the active phase of the first stage of labor. Methods Th...
Analysis of Drug Resistance Mutation-related Sites in 1 452 Chronic Hepatitis B Patients with Low Viral Load in Kunming Area
Tingting YU, Hongying WANG, Runwu ZHANG, Jing BAI, Dong PU, Dongling LI
2022, 43(9): 43-47. doi: 10.12259/j.issn.2095-610X.S20220927
Abstract(4454) HTML PDF(31)
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Objective To analyze and study the genotyping and drug resistance mutation sites of hepatitis B patients with low viral load in Kunming, so as to determine the difficulty of clinical antiviral treatment for low viral load hepatitis B patients and for...
Perinatal Risk Factors of Neonatal Hyperthyrotropinemia
Caiying ZHANG, Zhengping KUI, Qiong WANG, Xiaolong ZHAO, Xiaomei HOU, Zhiye QI
2022, 43(9): 48-52. doi: 10.12259/j.issn.2095-610X.S20220929
Abstract(4973) HTML PDF(33)
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Objective To investigate the association between neonatal Hyperthyrotropinemia (HT) and perinatal risk factors. Methods A case-control study was conducted among 109 newborns with HT (case group) and 127 newborns without HT (control group) in the Fir...
Studies on the Correlation of Early Blood Uric Acid Fluctuation after Bariatric Surgery
Yuanqing CAO, Xiangyu ZI, Yankun ZHU, Baohong YUAN
2022, 43(9): 53-58. doi: 10.12259/j.issn.2095-610X.S20220924
Abstract(3378) HTML PDF(19) Cited By (2)
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Objective To explore the correlation of early serum uric acid fluctuations in patients after the bariatric surgery. Methods From January 2021 to June 2022, 80 patients with the metabolic syndrome who were admitted to Yan'an Hospital of Kunming and c...
Virtual Reality Distraction Induces Hypoalgesia in Patients with Chronic Nonspecific Low Back Pain
Taibang CHEN, Jing WANG, Di DU, Xiaoqing HE, Wenbao ZHOU
2022, 43(9): 59-65. doi: 10.12259/j.issn.2095-610X.S20220910
Abstract(2548) HTML PDF(20) Cited By (3)
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Purpose To investigate whether a virtual reality game can reduce the chronic nonspecific low back pain and help patients recover. Methods In this randomized controlled trial, the patients with the chronic nonspecific low back pain were taken as the ...
Clinical Application of Doxazosin Mesylate in Female Overactive Bladder
Xiaoqian YANG, Yuquan ZHANG, Huitao WANG, Tongxin YANG, Tao CHEN, Yuting WENG, Kewei FANG
2022, 43(9): 66-69. doi: 10.12259/j.issn.2095-610X.S20220926
Abstract(2162) HTML PDF(24) Cited By (4)
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Objective To study the clinical therapeutic effect of doxazosin mesylate on female patients with overactive bladder (OAB) complicated with micturition symptoms. Methods A retrospective analysis was made of 68 female patients who were diagnosed with ...
An Analysis of PLA2G1B Expression and Prognosis in Patients with Lung Adenocarcinoma
Zhongshan ZHU, Zhou YANG, Chengchuan JIANG, Xiaobing LI, Dou REN, Cheng HUANG, Weiwei ZHANG, Xiangjun LI, Shunli ZHAO
2022, 43(9): 70-76. doi: 10.12259/j.issn.2095-610X.S20220912
Abstract(4298) HTML PDF(39) Cited By (1)
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Objective To analyze PLA2G1B gene expression, prognosis, immunologic features and potential therapeutic effects in patients with lung adenocarcinoma, based on the data-mining of public databases. Methods Data from TCGA and GEO database of LUAD were ...
Clinical Effect of Reoperation for Recurrent Glioma
Xiaofeng ZHU, Guangping ZHOU, Laicang WANG, Houjun ZHOU, Xin GENG, Hualin YU, Jinghui LI, Peng BAI
2022, 43(9): 77-83. doi: 10.12259/j.issn.2095-610X.S20220920
Abstract(2880) HTML PDF(22) Cited By (4)
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Objective To analyze the clinical effect of multimodality microsurgery on recurrent gliomas, and to explore the diagnosis and treatment of recurrent gliomas. Methods Data of 28 patients with recurrent GLIOMAS who underwent reoperation from September ...
Risk Factors for Hypoparathyroidism after Thyroidectomy
Wanyou JIA, Hongli LIU, Weiwei JIANG, Hongmin LI, Shuo ZHANG, Jimin FEI
2022, 43(9): 84-89. doi: 10.12259/j.issn.2095-610X.S20220904
Abstract(3477) HTML PDF(18) Cited By (5)
Abstract:
Objective To explore the risk factors of hypoparathyroidism (HypoPT) after thyroidec-tomy and analyze the relationship between the number of coexisting risk factors and the incidence of HypoPT, so as to guide the clinical treatment. Methods A total...
Application of Multimodal Ultrasound in Post-operative Monitoring of Transplanted Livers by Donors after the Brain Death
Yan SHEN, Yongfeng LI, Chunhua XIAO, Hong LI, Wei YANG, Shengning ZHANG, Yanqiong LV, Wandong YANG, Shilan. DING
2022, 43(9): 90-95. doi: 10.12259/j.issn.2095-610X.S20220917
Abstract(2970) HTML PDF(20) Cited By (1)
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Objective To explore the application value of multi-mode ultrasound in post-liver transplantation monitoring by combining two-dimensional gray scale ultrasound, CDFI, Spectral Doppler and CEUS in gray scale, blood flow and microperfusion examination ...
Observation of the Curative Effect of Enlarged and Opened Middle Turbinate Combined with Nerve Branch Block in Patients with Refractory Sinusitis
Linling ZHU, Chenggang WANG, Hongliang YANG, Xiangling WEN
2022, 43(9): 96-100. doi: 10.12259/j.issn.2095-610X.S20220919
Abstract(3741) HTML PDF(13) Cited By (2)
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Objective To investigate the curative effect of sinus enlargement and opening partial middle turbinate resection combined with nerve branch block in patients with refractory sinusitis. Methods A total of 60 patients with refractory sinusitis admitt...
The Relationship between Pregnancy Complications and Adverse Pregnancy Outcomes and Pre-pregnancy Weight and Weight Gain during Pregnancy
Li'e CHEN, Tingting LI
2022, 43(9): 101-106. doi: 10.12259/j.issn.2095-610X.S20220909
Abstract(2945) HTML PDF(22) Cited By (15)
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Objective To explore the influence and relationship of prepregnancy weight and pregnancy weight gain on pregnancy complications and adverse pregnancy outcomes, and to provide the evidence for the pregnancy health care, reducing pregnancy complication...
Treatment of Avulsion Fracture of Anterior Cruciate Ligament Tibial Insertion with Double Row Suture under Arthroscopy
Xinyu LIAO, Yaozhang ZHANG, Ruiying ZHONG, Dengjun YANG, Qiai ZHANG, Lu HE, Hong ZHANG, Yaxing ZHENG, Fuke WANG
2022, 43(9): 107-113. doi: 10.12259/j.issn.2095-610X.S20220906
Abstract(2860) HTML PDF(21) Cited By (1)
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Objective To investigate the effect of double row suture fixation on avulsion fracture of anterior cruciate ligament (ACL) tibial insertion under arthroscopy. Methods A total of 35 patients with avulsion fracture of anterior cruciate ligament tibial...
The Influence of Preoperative Mild Thrombocytopenia on Postpartum Hemorrhage after Cesarean Section
Aihua WANG, Yimei YANG, Yu SUN, Lei BAO
2022, 43(9): 114-117. doi: 10.12259/j.issn.2095-610X.S20220921
Abstract(2838) HTML PDF(17) Cited By (2)
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Objective The purpose of this study is to analyze whether mild thrombocytopenia is associated with an increased risk of postpartum hemorrhage in women undergoing cesarean section. Methods All women who underwent cesarean section in the department of...
Comparions of the Diagnostic Value between Digital Breast Tomosynthesis and Full-field Digital Mammography
Xia LI, Jin WANG
2022, 43(9): 118-124. doi: 10.12259/j.issn.2095-610X.S20220914
Abstract(4200) HTML PDF(73) Cited By (8)
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Objective To investigate the diagnosistic efficiency of digital breast tomosynthesis (DBT) in breast diseases. Methods 151 women with a clinically suspicious breast disease during Sept. 2017 to Sept. 2019 were enrolled into the study and all of the...
Analysis of Vitamin D Level in Pregnant Women and Infants in Kunming and Study on the Relationship between Fasting Blood Glucose Level and Vitamin D Level during Pregnancy
Yong YUAN, Xinyi LI, Yan FU, Yan ZHU
2022, 43(9): 125-129. doi: 10.12259/j.issn.2095-610X.S20220931
Abstract(5201) HTML PDF(95) Cited By (4)
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Objective To understand the vitamin D nutritional status of pregnant women and infants in Kunming by analyzing the serum level of 25 hydroxyvitamin D(25OHD), and to explore the relationship between vitamin D and the risk of gestational diabetes so as...
The Effectiveness of White Noise Intervention for Improving Subjective Sleep Quality and Anxiety of Militaries Living at the High Altitude
Xinyuan HUANG, Shu MA, Fanyi KONG, Mingsheng WANG
2022, 43(9): 130-134. doi: 10.12259/j.issn.2095-610X.S20220918
Abstract(2672) HTML PDF(20) Cited By (6)
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Objective To explore the efficacy and safety of white noise on improving the subjective sleep quality of soldiers in plateaus. Methods At a garrison of 3,800 meters, the Pittsburgh Sleep Assessment Scale (PSQI scale), anxiety self-assessment scale ...
Effect of VitD Supplementation on the Improvement of Autoimmune Thyroiditis in Childbearing Age Females
Chen WANG, Sha LI, Boxue ZHANG, Jinhua HE
2022, 43(9): 135-140. doi: 10.12259/j.issn.2095-610X.S20220907
Abstract(4734) HTML PDF(22) Cited By (3)
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Objective To investigate the effects of vitamin D supplementation on thyroid function, autoimmune antibody and serum 25 (OH) D levels in female patients with autoimmune thyroiditis (AT) in the reproductive age. Methods 94 childbearing age females wi...
Effects of Ranibizumab and Odix on the Microvascular Structure of the Macular Region
Jian ZHAO, Jiubing XIE, Liankai ZHAO
2022, 43(9): 141-146. doi: 10.12259/j.issn.2095-610X.S20220930
Abstract(2465) HTML PDF(14) Cited By (1)
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Objective To investigate the effect of ranibizumab and odix on the microvascular structure of the macular region in patients with retinal vein occlusion-macular edema (RVO-ME). Methods All patients with RVO-ME admitted and diagnosed in the ophthalmo...
Forensic Medicine Research
Determination of Scopolamine and Atropine in Blood and Urine by LC-MS / MS
Yuexin LIU, Fangdong TIAN, Xinyi LI, Gen XIONG, Xiangyu JIANG, Xian LI, Yanni LI
2022, 43(9): 147-154. doi: 10.12259/j.issn.2095-610X.S20220916
Abstract(3189) HTML PDF(19) Cited By (2)
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Objective To develop a LC-MS/MS method for the determination of scopolamine and atropine in human blood and urine after Datura stramonium poisoning. Methods Shim-pack GISR-HP C18 column was used for gradient elution with acetonitrile formic acid (0....
Reviews
Advances on the Relationship between Protein S-nitrosylation and Digestive System Tumors
Yu LV, Yibo HU, Jiaxin WANG, Youtong SU, Youguo DAI
2022, 43(9): 155-159. doi: 10.12259/j.issn.2095-610X.S20220911
Abstract(3131) HTML PDF(34)
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S-nitrosylation modification is a selective and reversible post-translational modification of protein by high concentration of nitric oxide (NO), which is related to a variety of cellular processes and tissue homeostasis. Most digestive system tumors...
Glucose Transport in Human Placenta and the Effect of GDM on Placental Glucose Transport
Yindong HE, Jun ZHANG, Hua HUANG, Ruming LIU, Xi WANG
2022, 43(9): 160-165. doi: 10.12259/j.issn.2095-610X.S20220903
Abstract(2787) HTML PDF(35) Cited By (3)
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Placenta plays an important role in the process of glucose transfer from maternal to fetus. The normal structure and function of the placenta guarantee the fetus to take up glucose effectively from maternal side over the gestation. Glucose transplace...
Teaching Research
Application of TBL-PBL-CBL Combined Teaching Mode in the Clinical Practice of Cardiology
Guofu ZHU, Ziyu YI, Shuai ZHENG, Tao LI, Tianshu CHU, Zhimin RUAN, Qian ZHANG, Mingli ZHOU, Yi DUAN
2022, 43(9): 166-171. doi: 10.12259/j.issn.2095-610X.S20220902
Abstract(3683) HTML PDF(44) Cited By (13)
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Objective To explore the effect of TBL-PBL-CBL combined teaching mode in the clinical practice of cardiology, and provide a new training direction for high-quality doctors. Methods 80 students participating in the clinical practice in the Cardiology...
Nursing Forum
Application of FOCUS-PDCA Program Intervention Mode in Continuous Care of Discharged Patients with Stroke
Lishuang LIU, Ping RAO, Lang LANG, Ping ZHANG
2022, 43(9): 172-176. doi: 10.12259/j.issn.2095-610X.S20220922
Abstract(3561) HTML PDF(24) Cited By (8)
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Objective To explore the effect of continuous nursing intervention for discharged stroke patients based on FOCUS-PDCA procedure. Methods 100 patients with cerebral apoplexy who were about to be discharged from our hospital from May 2020 to February ...