2023 Vol. 44, No. 7

Original Articles Basic of Medicine
Effects of Euonymine on Proliferation,Migration,and Cell Cycle of HUVECs and VSMCs
Li ZHANG, Xi ZHAO, Huaxiang ZHAO, Bao XIONG, Jie XU, Guangping TANG, Zhuo YU, Peng CHEN
2023, 44(7): 1-8. doi: 10.12259/j.issn.2095-610X.S20230723
Abstract(2892) HTML PDF(40)
Abstract:
Objective To investigate the effects of Euonymine on isolated cultured human umbilical vein endothelial cells (HUVECs) and human vascular smooth muscle cells (VSMCs), so as to elucidate the possible mechanism of Euonymine in prevention and treatment ...
Application of Nanopore Sequencing in Tumor with Infection
Xi LIU, Xin LIU, Jingjing CAI, Yaxi DU, Hongsheng LI, Yongchun ZHOU
2023, 44(7): 9-15. doi: 10.12259/j.issn.2095-610X.S20230710
Abstract(2924) HTML PDF(15)
Abstract:
Objective To evaluate the clinical application value of nanopore sequencing in tumor patients with concurrent infectious diseases and to provide a new detection method for rapid and sensitive diagnosis of infectious diseases in tumor patients. Metho...
Common Genotypes Screening and Clinical Characteristics of G6PD Deficiency in Dai People of Gestational Age in Yingjiang, Yunnan Province
Xinchao CHEN, Jiehan JIANG, Qing XIONG, Qiuhua WU, Suying ZHANG, Bihui YANG, Jie ZHANG, Yanxiang DUAN, Ming HE
2023, 44(7): 16-21. doi: 10.12259/j.issn.2095-610X.S20230702
Abstract(6544) HTML PDF(38)
Abstract:
Objective To analyze the screening results and genotype distribution characteristics of glucose-6-phosphate dehydrogenase (G6PD) deficiency among Dai people in Yingjiang County, Yunnan Province, and to provide a scientific theoretical basis for its p...
Correlation of ERAP Gene Polymorphism with Antibody Response Induced by Sequential Immunization of Polio Vaccine
Yuhan SHI, Jing LI, Shuyuan LIU, Ting ZHAO, Jingsi YANG, Li SHI, Jiangli LIANG
2023, 44(7): 22-28. doi: 10.12259/j.issn.2095-610X.S20230711
Abstract(2904) HTML PDF(11)
Abstract:
Objective To analyze the relationship between endoplasmic reticulum aminopeptidases (ERAP) gene polymorphisms and serum polio antibodies induced by sequential polio vaccine immunization. Methods A total of 243 Zhuang individuals were selected from t...
The Relationship between Arsenic Exposure and DNA Damage of EGFR,PTEN,Kras,and PIK3CA Genes in Arsenic Factory Workers
Jiang WU, He MA, Jinyun JIANG, Na LIU, Ruihuan ZHAO, Yuefeng HE
2023, 44(7): 29-33. doi: 10.12259/j.issn.2095-610X.S20230717
Abstract(2701) HTML PDF(10) Cited By (1)
Abstract:
Objective To explore the relationship between DNA damage and urinary arsenic metabolism in four genes of EGFR, PTEN, Kras and PIK3CA in workers exposed to arsenic in arsenic factories. Methods A total of 78 first-line occupational arsenic exposure w...
Mechanism of Osteoking Improving Osteoarthritis based on Network Pharmacology and DDM Rats
Shaoyou DENG, Rong LI, Jintao LI, Yulan ZHAO, Peijin WANG, Hong ZHENG
2023, 44(7): 34-39. doi: 10.12259/j.issn.2095-610X.S20230701
Abstract(2824) HTML PDF(21) Cited By (3)
Abstract:
Objective To explore the potential mechanism of Osteoking (OK) in the treatment of Osteoarthritis (OA) and preliminarily verify it with DMM rats. Methods TCMSP database was used to collect potential targets of OK, GeneCards database and OMIM were us...
The Influencing Factors of Self-rated Health Status of Elderly Patients with Hypertension in Yi Rural Areas of Yunnan Province
Qichuan HU, Lichun JIANG, Fujing FENG, Yajing ZHANG, Ximeng ZHAO, Yueyun ZHANG, Hechuan ZHANG
2023, 44(7): 40-46. doi: 10.12259/j.issn.2095-610X.S20230704
Abstract(3613) HTML PDF(18) Cited By (3)
Abstract:
Objective To investigate the self-rated health status of elderly hypertensive patients in rural areas of Yi people, Yunnan province, and explore the influencing factors. Methods A convenience sample of 980 elderly hypertensive patients from rural ar...
Clinical Research
Analysis of Clinical Diagnosis and Treatment of Nonfunctional Pancreatic Neuroendocrine Neoplasms
Jing LI, Lin WANG, Qiang KANG, Yuehua LI, Hong ZHU, Yixuan CHEN, Xuefen LEI
2023, 44(7): 47-51. doi: 10.12259/j.issn.2095-610X.S20230706
Abstract(2940) HTML PDF(20) Cited By (1)
Abstract:
Objective To investigate the prognosis of surgical resection in patients with nonfunctioning pancreatic neuroendocrine neoplasms (NF-pNENs). Methods The clinical and follow-up data of 45 patients who were pathologically confirmed NF-pNENs in the Sec...
Analysis of the Characteristics of Tibetan Patients with Orthodontic Treatment in Shangri-la of Diqing Prefecture
Jiye XIE, Xin WEN, Chun LI, Runqin ZHANG, Xuemei YANG, Jianli ZHANG, Yanhua XU
2023, 44(7): 52-56. doi: 10.12259/j.issn.2095-610X.S20230718
Abstract(3044) HTML PDF(9)
Abstract:
Objective To determine the characteristics of Tibetan patients with orthodontic treatment in Shangri-la of Diqing prefecture, and provide scientific evidence for dentists. Methods 249 Tibetan orthodontic patients (90 males and 136 females) between t...
Clinical Investigation on Foure-dimensional Left Atrial Automatic Quantitative Technology in Evaluating Left Atrial Volume and Function
Yueyue TANG, Hanning YANG, Youliang JIN, Shumin LI, Yongping LU
2023, 44(7): 57-63. doi: 10.12259/j.issn.2095-610X.S20230713
Abstract(2576) HTML PDF(32)
Abstract:
Objective To explore the role of four-dimensional left atrial automatic quantitative technology in evaluating the volume and function of the left atrium in non-selective continuous patients, and to preliminarily explore its accuracy and repeatability...
Analysis of Clinical Risk Factors for Idiopathic Hypogonadotropic Hypogonadism
Wenlin ZHOU, Ben NIU, Heng SU
2023, 44(7): 64-68. doi: 10.12259/j.issn.2095-610X.S20230727
Abstract(2819) HTML PDF(12)
Abstract:
Objective To analyze the clinical risk factors in idiopathic hypogonadotropic hypogonadism patients (IHH). Methods We selected 120 patients with hypogonadism from the Endocrinology Department of the First People's Hospital of Yunnan Province from Ja...
M2 Macrophage-derived Exosome miR-1246 Regulates the Growth and Invasion of Gastric Cancer Cells
Liang ZHANG, Baoquan WANG, Xifeng LEI, Xu WANG, Yang KE, Wei ZHANG
2023, 44(7): 69-77. doi: 10.12259/j.issn.2095-610X.S20230724
Abstract(3060) HTML PDF(20) Cited By (1)
Abstract:
Objective To investigate the effects of M2 macrophage-derived exosome miR-1246 on the proliferation, apoptosis and invasion of AGS cells. Methods After induction of M2 macrophages using LPS and IFN-γ, their exosomes were isolated and identified by t...
Analysis of Prognostic Risk Factors in Patients with Septic Shock Based on Circulatory and Cellular Immune Response Indicators
Qiang WANG, Dexing YANG, Weiyu ZHOU, Jiefu TANG, Kai FU, Zhenfang WANG, Shengzhe LIU, Min LI, Ying LUAN, Rong LIU
2023, 44(7): 78-87. doi: 10.12259/j.issn.2095-610X.S20230716
Abstract(2681) HTML PDF(17) Cited By (1)
Abstract:
Objective To investigate the prognostic risk factors of patients with septic shock based on circulatory and cellular immune effects, to accurately regulate the noradrenaline dose, alleviate immune function suppression, and improve the success rate of...
Pulmonary Function and Respiratory Muscle Strength in Mild to Moderate Adolescent Idiopathic Scoliosis Patients
Kerong LI, Zhi ZHAO, Moxian CHEN, Lijuan AO, Fanyuan MENG
2023, 44(7): 88-93. doi: 10.12259/j.issn.2095-610X.S20230707
Abstract(3332) HTML PDF(17) Cited By (2)
Abstract:
Objective To investigate the correlation between pulmonary function and respiratory muscle strength in adolescent idiopathic scoliosis (AIS) patients compared to healthy subjects of the same age, and to investigate the correlation between the size of...
Study on Serum Markers of Intestinal Barrier Damage in Heroin Addicts at Different Withdrawal Times
Yuansen LI, Cheng CHEN, Yan TIAN, Ruo SHU, Yu XU, Yuanhua LI
2023, 44(7): 94-99. doi: 10.12259/j.issn.2095-610X.S20230709
Abstract(2617) HTML PDF(9)
Abstract:
Objective To investigate the mechanisms of intestinal barrier damage after heroin withdrawal by analyzing changes in markers of intestinal barrier damage at different withdrawal times, providing a new direction for the relationship between altered ps...
Pharmacokinetic Study of Dexmedetomidine in Patients with Different Degrees of Burn
Ling ZHAO, Shulan JIAO, Yongyu SI, Liu YANG, Yinghui BU
2023, 44(7): 100-104. doi: 10.12259/j.issn.2095-610X.S20230725
Abstract(2674) HTML PDF(5)
Abstract:
Objective To investigate the pharmacokinetics of dexmedetomidine in burn patients with different degrees in order to improve the quality of anesthesia in burn patients. Methods Forty-five burn patients undergoing elective surgery were selected in th...
Investigation on Occupational Exposure and Protection of Cytotoxic Drugs among PIVAS Personnel in Yunnan Province
Hongyin ZHANG, Hongmei ZHU, Huiqin ZHANG, Hongwen YAO, Guirong ZHU, Lin LI
2023, 44(7): 105-112. doi: 10.12259/j.issn.2095-610X.S20230722
Abstract(2998) HTML PDF(21) Cited By (2)
Abstract:
Objective To understand the occupational exposure situation of staff in the pharmacy intravenous admixture services (PIVAS) of Yunnan Province and identify the issues related to occupational protection in PIVAS staff. Methods Based on the “Quality M...
Analysis of Subanesthetic Doses of Esketamine and Propofol in Three-dimensional Afterloading Treatment of Cervical Cancer
Dongyang ZHANG, Zheng LI, Yahong WANG, Guangshun LIU, Yuhang QUAN, Xiang MA
2023, 44(7): 113-118. doi: 10.12259/j.issn.2095-610X.S20230721
Abstract(2596) HTML PDF(4) Cited By (3)
Abstract:
Objective To investigate the effects of combined subanesthetic doses of esketamine and propofol anesthesia in three-dimensional after loading treatment of cervical cancer. Methods One hundred patients who received three-dimensional afterloading tre...
Effects of High-frequency Repetitive Transcranial Magnetic Stimulation (rTMS) on Cognitive Function in Patients with Traumatic Brain Injury
Jing GAO, Fengjie SONG, Yu CHEN, Run ZI, Wei ZHANG
2023, 44(7): 119-124. doi: 10.12259/j.issn.2095-610X.S20230703
Abstract(2894) HTML PDF(19) Cited By (2)
Abstract:
Objective To observe the effects of rTMS on cognitive function in patients with traumatic brain injury. Methods A total of 160 patients with traumatic brain injury admitted to Yan’an Hospital of Kunming City from January 2021 to January 2022 were se...
Content Analysis of Concentrated Growth Factor Fibrin Gel in Patients with Type 2 Diabetes Mellitus
Yanbo YUAN, Zhaojuan RUAN, Liangju CAO, Wanjuan YANG, Yu JIANG, Xue ZHOU
2023, 44(7): 125-129. doi: 10.12259/j.issn.2095-610X.S20230720
Abstract(2706) HTML PDF(8)
Abstract:
Objective To study the growth factors and its contents in the concentrated growth factor (CGF) fibrin gel for type 2 diabetes mellitus (T2DM). Methods T2DM patients who needed tooth extraction and implantation under insulin hypoglycemic were selecte...
Analysis of Incidence Rate and Risk Factors of Preeclampsia Based on A Maternal and Infant Health Cohort
Liping WANG, Puxian PENG, Aihan WEN, Yuan ZHANG, Yazhou SHEN, Tao WANG, Songyuan TANG, Xingmei DENG
2023, 44(7): 130-135. doi: 10.12259/j.issn.2095-610X.S20230715
Abstract(3162) HTML PDF(17) Cited By (4)
Abstract:
Objective To investigate the influencing factors of preeclampsia to provide basis for prediction and treatment of preeclampsia. Methods In Qujing Maternal and Child-care Hospital, 11679 pregnant women who were included in the prospective cohort of m...
Value Evaluation of New Markers AFP-L3 and PIVKAⅡ in the Diagnosis of Liver Cancer
Liqiang LAN, Jing LI, Qingbo REN
2023, 44(7): 136-141. doi: 10.12259/j.issn.2095-610X.S20230705
Abstract(2889) HTML PDF(31)
Abstract:
Objective To investigate the diagnostic value of AFP-L3 and PIVKAⅡ in liver cancer. Methods A total of 3066 patients with chronic liver disease who were admitted to Qingdao Sixth People’s Hospital from January 2019 to January 2022 were selected as o...
Characteristics and Correlation Analysis of the Psychological Status of 1035 Elderly People in the Place in Sichuan Province
Gui ZHOU, Yongxue YANG, Jia LIU, Lei FENG
2023, 44(7): 142-147. doi: 10.12259/j.issn.2095-610X.S20230726
Abstract(3081) HTML PDF(13) Cited By (2)
Abstract:
Objective To understand the psychological status of the elderly, through a survey of the elderly in Chengdu, to explore the correlation between the different psychological status of the elderly, to find the cut-in point for the related departments to...
Reviews
Research Progress on Intestinal Microflora and Non-alcoholic Fatty Liver Disease in Children
Lu LI, Yunfen TIAN
2023, 44(7): 148-155. doi: 10.12259/j.issn.2095-610X.S20230708
Abstract(2924) HTML PDF(26) Cited By (2)
Abstract:
Pediatric non-alcoholic fatty liver disease (NAFLD) is the most common cause of pediatric chronic liver disease worldwide, and its incidence is gradually increasing with the global epidemic of obesity, but there is no standardized and effective treat...
Potential Therapeutic Targets and Research Progress of Related Drugs of Heart Failure
Mei YANG, Ping WANG, Hui YANG, Gonghao HE
2023, 44(7): 156-161. doi: 10.12259/j.issn.2095-610X.S20230719
Abstract(3529) HTML PDF(96) Cited By (1)
Abstract:
Heart failure is one of the main causes of death in cardiovascular diseases. With the increasing prevalence of heart failure, it has become the main research direction to explore new therapeutic targets and further reduce the mortality of patients. T...
MSCs Promote Autophagy to Alleviate Liver Injury in NASH by Regulating AMPK/mTOR Axis
Chenchen LIANG, Jianpeng GAO
2023, 44(7): 162-167. doi: 10.12259/j.issn.2095-610X.S20230728
Abstract(2690) HTML PDF(25)
Abstract:
NASH is the characteristic pathological manifestation of the liver in MAFLD, which is a key turning point in the development of MAFLD from a relatively benign and reversible stage to liver injury and even cirrhosis and hepatocellular carcinoma. Recen...
Teaching Research
Distribution and Influencing Factors of Kolb Learning Style Type among Medical Students
Jiangming WANG, Hongmin LIANG, Hongbin LI, Jingyuan MA, Pinlin LIU, Wenxing FAN
2023, 44(7): 168-172. doi: 10.12259/j.issn.2095-610X.S20230714
Abstract(3159) HTML PDF(26) Cited By (3)
Abstract:
Objective To understand the distribution of Kolb learning style of medical students and analyze its influencing factors, so as to provide a theoretical basis for the reform of medical teaching. Methods Kolb Learning style Scale and 10 related factor...
Application of CBCL in Standardized Training of Resident Doctors
Shibo SUN, Chen CHEN, Min LI, Zhuang LUO, Yunjiao HOU, Linzhu YANG
2023, 44(7): 173-176. doi: 10.12259/j.issn.2095-610X.S20230712
Abstract(3300) HTML PDF(23) Cited By (2)
Abstract:
Objective To explore the role of case-based collaborative learning (CBCL) in the standardized training of residents. Methods All 64 residents included in this study were randomly divided into two groups: the experimental group (n = 32) and the cont...